Tumors analyzed after two weeks (6 treatments) of treatment showed full CDK7 engagement in YKL-5-124 and combination-treated animals (Figure 5F), with similar effects as the established cell line tumors on IHC analysis (Supplementary Figure 5D) Altogether, compared with each single agent, combined treatment resulted in a more pronounced therapeutic effect in mouse models of NB. This evidence concerns the gene CDK7 and neuroblastoma.