Furthermore, as shown in the univariate analyses reported in Table 4, the absence of preexisting comorbidity (P = 0.088) and serum CA-125 levels (P = 0.005) together with the absence of radiological evidence of pleural effusion (P = 0.007), tumor bilaterality (P = 0.037), significant preoperative tumor size (P = 0.059), peritoneal thickening (P = 0.001), and retroperitoneal lymph nodes (P = 0.001) were the likely predictors of OTR in patients with advanced EOC. The gene discussed is MUC16; the disease is Pleural effusion.