Another recent work demonstrated that GR binding to GREs in β-arrestin 1 and 2 and modulates their expression and alters G-protein coupled receptor (GPCR) signaling which may have beneficial implications in combination therapy using corticosteroids and GPCR-based drugs in the treatment of asthma and COPD [133]. Here, NR3C1 is linked to chronic obstructive pulmonary disease.