NR3C1 and Hyperglycemia: At the same time, mediated by GR homodimer TA regulates GR signaling linked to gluconeogenesis, lipid and protein catabolism, and often mediates the development of atrophic effects in different tissues (such as skin and muscle atrophy) as well as some metabolic adverse effects (hyperglycemia, steroid-induced diabetes) [7, 11–13].