Indeed, when using a Cre-inducible transgenic mouse model (Mx-Cre), we found that the systemic knockout of RBP-J in adult mice, in which RBP-J is deleted with high efficiency in both the hematopoietic system and the liver, led to the aggravation of CCl4-induced hepatic fibrosis (data not shown). This evidence concerns the gene RBPJ and Hepatic fibrosis.