CDH5 and Hepatic fibrosis: Furthermore, we have previously shown that myeloid-specific disruption of RBP-J using Lyz2-Cre RBP-Jflox/flox or RBP-J deficiency in hepatic myofibroblasts mediated by Sm22α-CreER RBP-Jflox/flox could reduce hepatic fibrosis in mice 12,28, while endothelial Notch activation with CDH5-CreER NICD elicited the opposite effect 29.