In addition to killing tumor cells, chemotherapeutics, such as anthracyclines, taxanes, mitoxantrone, and oxaliplatin, induce immunogenic cell death (ICD), which sensitizes tumors to programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) blockade immunotherapy 1-3. The gene discussed is PDCD1; the disease is neoplasm.