SQSTM1 and Alzheimer disease: We found that over-expression of CCZ1-MON1A significantly increased the protein level of LC3-II and reduced SQSTM1 level in 3xTg AD mice and WT mice (Figure 8A-C, Figure S7A-F), suggesting that autophagy was enhanced in CCZ1-MON1A-injected 3xTg AD mice and WT mice.