CCZ1 and Alzheimer disease: To confirm the effects of CCZ1-MON1A in regulating AD-related behavioral and neuropathological changes, AAV9-Flag-ccz1 /AAV9-Flag-mon1a (AAV-CM) or empty vector AAV-FLAG (AAV-VE) were stereotaxically injected into both sides of the hippocampus of 3xTg AD mice and WT C57 mice 28.