Using the MM1S cell line, Lovén et al. identified super-enhancers associated with key MM genes, including MYC, IRF4, PRDM1, XBP1, CCND2, PIM1, BCL-xL and MCL1 39.We identified a number ranging from 607 to 2510 predicted super-enhancers in each of the HMCLs (Supplementary Table 5). The gene discussed is XBP1; the disease is Miyoshi myopathy.