We have identified super-enhancers (SE) associated with genes involved in the biology of MM, such as MAF, MYC, CCND1, CCND2, TRAF3 or NSD2, and repressive domains, characterized by the co-localization of the H3K9me3 and H3K27me3 modifications on promoters of genes with potential tumor suppressor function. This evidence concerns the gene NSD2 and Miyoshi myopathy.