Of the eighteen genes, thirteen genes (ARHGEF5, DEF8, GRID2IP, HDAC9, HSPA1L, KDM4C, P4HA3, PAG1, SEMA6A, SFMBT2, THEMIS2, ZFP2 and ZNF518B) were down-regulated in HMCLs compared to primary MM cells (Supplementary Figure 12). This evidence concerns the gene THEMIS2 and Miyoshi myopathy.