Interestingly, 21 genes (HK2, HNRNPC, HSPA9, ILF3, LDHB, MDH1, MYBPC2, NCL, NUDC, PARP1, PDIA6, PRPS1, RPL13A, RPL27A, SF3B2, SLC25A39, SMARCA4, STC2, TNPO2, TPR and YWHAQ) were significantly overexpressed in HMCLs compared to plasma cells of MM patients (Supplementary Figure 5), suggesting that genes may play a role in disease progression and independence of MM cells from micro-environment. This evidence concerns the gene MDH1 and Miyoshi myopathy.