SPN and cancer: Moreover, concerning the 28 genes composing the SE-risk score, the prognostic value of 7 genes (BSG, HK2, HSPA9, IL10, PARP1, PDIA6 and SLC7A5) has already been described in MM 69-79 while the expression of HNRNPC, ILF3, LDHB, MDH1, NCL, PRPS1, RPL8, RPL13A, RPL35, SMARCA4, SPN, STC2 and THY1 was described to be associated to tumorigenesis, drug resistance and/or poor prognosis in other cancers 80-93.