Cheng et al. 188 achieved the synthesis of multivalent antibody-retargeting exosomes (SMART-Exos) that express T cell CD3 and cancer-associated EGFR monoclonal antibody not only induce T cells to cross-link with EGFR-expressing breast cancer cells and can induce strong anti-tumor immunity in vivo. This evidence concerns the gene EGFR and breast cancer.