To extend our findings to patients with liver fibrosis, we further analyzed a public cirrhosis dataset and experimentally the non-tumorous regions of HCC patients with fibrosis; cirrhotic patients exhibited significantly higher transcript levels of ROCK1, but not ROCK2 than healthy individuals in a human cirrhotic liver cohort database (GSE25097) (Figure 8E). This evidence concerns the gene ROCK2 and hepatocellular carcinoma.