Analysis of public GEO databases obtained from patients with HBV-associated acute liver failure (HBV-ALF) (GSE38941) indicated that hepatic ROCK1 transcript levels were higher in patients with submassive hepatic necrosis (SHN) or massive hepatic necrosis (MHN) compared to healthy individuals, whereas ROCK2 mRNA levels were not significantly affected (Figure 8A). The gene discussed is ROCK1; the disease is acute liver failure.