On the other hand, CAFs can secrete multiple chemokines and cytokines, such as transforming growth factor-β (TGFβ), CC-chemokine ligand 2 (CCL2), and interleukin-6 (IL-6), in order to recruit immunocytes with inhibitory functions in the tumor stroma, thereby facilitating immune evasion 7. This evidence concerns the gene IL6 and neoplasm.