We were the first to discover and verify that KDM1A is involved in the regulation of stemness and chemosensitivity in thyroid carcinoma and demonstrate that KDM1A activates the Wnt pathway by inhibiting APC2 and DKK1 transcription through its demethylation function on histones of the APC2 promoter region and nonhistone HIF-1α. Here, APC2 is linked to thyroid gland carcinoma.