From the overall bioinformatics data, the effect of vitamin C on HIE is achieved by regulating the IL-17 signaling pathway, C-type lectin receptor signaling pathway, Th17 cell differentiation, B cell receptor signaling pathway, Nod-like receptor signaling pathway, tumor necrosis factor signaling pathway, T cell receptor signaling pathway, HIF-1 signaling pathway, and other signaling pathways, most of which are related to immunity and inflammation mediated by cerebral ischemia and hypoxia. Here, HIF1A is linked to brain ischemia.