Overall, the emerging methods of network pharmacology, molecular docking, and molecular dynamics simulation were first used to systematically and intuitively reveal the mechanism and pharmacology of vitamin C in treating HIE through 4 targets (HIF1A, CASP1, PTGS2, and PPARG) working together with the IL-17 signal pathway, C-type lectin receptor signal pathway, HIF-1 signal pathway, and other immune and inflammation-related multisignal pathways, indicating that vitamin C may be one of the effective drugs for the treatment of HIE. Here, HIF1A is linked to perinatal asphyxia.