The JAK/STAT pathway is considered as one of the major signaling pathways involved in sepsis (12) and is a part of many key cytokine signaling pathways in the pathogenesis of sepsis, such as interleukin (IL)-4, IL-6, IL-10, IL-12, and interferon (IFN)-γ (13–15). This evidence concerns the gene IL4 and Sepsis.