The proportions of Th1 and Th17 CD4+ T cells in the spleen of aged sepsis rats were markedly increased at the early onset and gradually decreased thereafter; correspondingly the proportions of Th1 and Th17 cells were reduced after MSCs treatment, and the ratios of Th1/Th2 and Th17/Treg cells were also decreased notably(Figures 4J–P). Here, CD4 is linked to Sepsis.