In the early onset of sepsis, the body responds to infection with strong immune responses, that are manifested by the massive mobilization of pro-inflammatory cells and pro-inflammatory factors (16), which significantly elevates the levels of pro-inflammatory cytokines such as IL-1β and IL-6, and causes an imbalance in the helper T cell (Th) 1/Th2 and Th17/Treg ratios (17–19). This evidence concerns the gene IL1B and infection.