In line with this, in infected adults also transiently higher frequencies of CD4+ TCM and TEMRA cells expressing CD38/HLA-DR were observed early after infection, and in both infected children and infected adults, transiently higher frequencies of CD8+ T cells expressing CD38/HLA-DR were observed within the TCM/TEM/TN cell subsets at the earlier time points after infection. This evidence concerns the gene CD4 and infection.