Furthermore, the up-regulated lncRNA ZFAS1 (155, 191), HIX003209 (156), and XIST (192) and down-regulated lncRNA LINC01197 (193), GAS5 (154), and OIP5-AS1 (194) also sponged miRNAs, thereby participating in cell proliferation, differentiation, apoptosis, and inflammation in synovial tissue of RA via ZFAS1/miR-2682-5p/ADAMTS9 axis, ZFAS1/miR-296-5p/MMP-15 axis, HIX003209/miR-6089/TLR4 axis, lncRNA XIST/let-7c-5p/STAT3 axis, LINC01197/miR-150/THBS2 axis, GAS5/miR-128-3p/HDAC4 axis, and OIP5-AS1/miR-448/PON1, respectively. This evidence concerns the gene LETR1 and rheumatoid arthritis.