Classical actors of the exocytotic process such as PLD1 participate in these trafficking events (71).The activation of FcγR-mediated phagocytosis pathway and up-regulation of PLD1, Pla2g4a, Ppap2b gene expression was found in 10°C infection group, suggesting that the phagocytosis of mIgM+ B lymphocytes could be activated at low temperature during HIRRV infection. This evidence concerns the gene PLD1 and infection.