In this study we applied high-throughput repertoire sequencing and TCR profiling to sorted populations of naïve (CD45RA+) and memory (CD45RO+) CD4+ and CD8+ lymphocytes derived from MS patients followed longitudinally out to 36 months post-AHSCT in order to investigate the clonal kinetics of immune reconstitution. Here, CD4 is linked to myeloid sarcoma.