Di et al. (106) found that in an inducible pseudophosphorylated tau (pathological human tau, PH-Tau) mouse model, low basal levels of PH-Tau (4% of endogenous tau) resulted in significant cognitive deficits, a decrease in the number of synapses in the CA1 region, a reduction in synaptic proteins, and localization to the nucleus. This evidence concerns the gene MAPT and Cognitive impairment.