Under LPS and dual hypoxia stimulation, destabilized Pellino1 (Ser39 phosphorylation and turnover) induced by death-associated protein kinase 1 (DAPK1) leads to the release of TRIF-RIP1 signalosome to recruit caspase-8 and induces tubular damage and cell apoptosis in acute kidney injury (AKI) model (98). Here, CASP8 is linked to acute kidney injury.