PTGS2 and brain ischemia: Pellino1 positively regulates the production of inflammatory factors in MyD88-dependent TLR signaling (69, 70) as MyD88 deficiency hindered the expression of Pellino1, NF-κB, IL-1β, IL-6, Beclin-1, and cyclooxygenase-2 (COX-2) in a cerebral ischemia/reperfusion (I/R) mouse model (70).