Under LPS and dual hypoxia stimulation, destabilized Pellino1 (Ser39 phosphorylation and turnover) induced by death-associated protein kinase 1 (DAPK1) leads to the release of TRIF-RIP1 signalosome to recruit caspase-8 and induces tubular damage and cell apoptosis in acute kidney injury (AKI) model (98). The gene discussed is DAPK1; the disease is acute kidney injury.