AFP and chronic hepatitis B virus infection: Our data indicated that AFP serologically positive was inadequate for the diagnosis of HCC, although it is still important to monitor the occurrence and prognosis of HCC in patients with chronic hepatitis B and HCC differentiation, size, and vascular invasion have strong relationships with AFP, The AFP level at diagnosis was an independent risk predictor associated with pathological grade, progression, and survival(Xu et al., 2012; Liu et al., 2013; Chun et al., 2015; Meng et al., 2016; Yao and Lu, 2016; Bai et al., 2017; Yang et al., 2018).