Ebastine and Loratadine are histamine receptor 1 (HR1) antagonists that are routinely used in the clinics for the treatment of allergy (Goyal et al., 2017; Drummond and Lester, 2018; Keerthana and Vidyavathi, 2018; Sastre, 2020). The gene discussed is CDCA7L; the disease is allergic disease.