Compared with PTMC harboring WT-BRAF, PTC harboring BRAF V600E mutation had a crude OR of 2.55 (1.06–6.12, p = 0.036) for lymph node metastasis and remained significant after adjustment for age and gender [3.01 (1.26–8.68), p = 0.015]. This evidence concerns the gene BRAF and metastatic malignant neoplasm in the lymph nodes.