The above observations indicate that EZH2 is essential for E2 pro-oncogenic actions, and since E2 could alternatively modulate EZH2 activity via nongenomic signaling involving ERs (ERα and ERβ) (36), we decided to explore whether there is a relationship between EZH2 and ERs expression in GBM. The gene discussed is EZH2; the disease is glioblastoma.