Regarding miR-222, the targets of it were mainly involved in cell cycle, PI3K-Akt signaling pathway, miRNAs in cancer, DNA replication, sphingolipid signaling pathway, pathways in cancer, FoxO signaling pathway, AMPK signaling pathway, proteoglycans in cancer, central carbon metabolism in cancer, mRNA surveillance pathway, thyroid hormone signaling pathway, RNA transport, Hippo signaling pathway, focal adhesion and RNA degradation. The gene discussed is TG; the disease is cancer.