Based on KEGG pathway analysis, the target genes of miR-221 were significantly enhanced for proteoglycans in cancer, miRNAs in cancer, pathways in cancer, cell cycle, FoxO signaling, neurotrophin signaling, Epstein-Barr virus infection, p53 signaling pathway, and Ras signaling pathway. Here, TP53 is linked to Epstein-Barr virus infection.