The co-existence of FTD or cognitive impairment was found in patients with seven VCP mutations (p.K60R, p.D98V, p.R155C, p.R159G, p.R191Q, p.R191P, and p.R487H) (5, 17, 44, 45, 52, 56, 60), while PDB was diagnosed in ALS patients with six VCP mutations (p.R93C, p.G128A, p.R155C, p.M158V, p.R159G, and p.R159C) (5, 6, 45, 53, 56, 58). Here, VCP is linked to amyotrophic lateral sclerosis.