In MS, a disease in which many have felt that the autoimmune response is directed against CNS myelin, some have found that CSF OCBs appear not to be directed against myelin antigens (137), while others have found that the target of the CNS immune response in some patients with MS is the myelin antigen, myelin oligodendrocyte glycoprotein (138). The gene discussed is OMG; the disease is myeloid sarcoma.