Importantly, our results confirm a possible interaction between Nrg4 and obesity (Little et al., 2014; Ma et al., 2016; Saeidi et al., 2020b), and suggest a positive effect of exercise training on obesity and lipid profiles that may be mediated by Nrg4. The gene discussed is NRG4; the disease is obesity due to melanocortin 4 receptor deficiency.