Moreover, an impaired function of antioxidant enzymes caused by genetic variation, such as deletion of Gpx1 and Sod1 in knock-out mouse models, can lead to both ARHL and NIHL (Ohlemiller et al., 2000b; McFadden et al., 2001; Fortunato et al., 2016). The gene discussed is GPX1; the disease is noise induced hearing loss.