Research studies based on NACC registry data suggest that different modifiable factors such as sleep disturbance, depression and traumatic brain injury, as well as the non-modifiable factors including genetic biomarkers as apolipoprotein E (APOE) or abnormal aggregation of proteins like alpha synuclein and TDP-43 as potential risks of dementia and AD development (Burke et al., 2016; Bayram et al., 2019). This evidence concerns the gene APOE and depressive disorder.