However, there are several lines of evidence which disagree with this hypothesis: (i) heavy amyloid β loads have been found in many healthy seniors in postmortem brains (Katzman et al., 1988) without causing any cognitive impairment; (ii) amyloid β load is not correlating well with cognitive decline, rather, Tau levels are more relevant (Karran and De Strooper, 2016); (iii) anti-Aβ treatment is ineffective in clinical trials despite clear decrease in patients’ amyloid β load. Here, MAPT is linked to Mental deterioration.