A number of T2DM-related chromosomal regions have been identified through linkage studies (CAPN10, ENPP1, HNF4A, and ADIPOQ) and candidate-gene studies (PPARG and KCNJ11) coding variants being two of the few that have been effectively duplicated in a cell culture environment (Sladek et al. 2007). Here, ENPP1 is linked to type 2 diabetes mellitus.