SCN5A and atrial fibrillation: In addition, we found a rare, enriched missense variant in FG (rs45620037:A; Thr220Ile; MAF = 0.11% (UKB) and 0.47% (FG); SIFT = 0.03, PolyPhen = 0.96) in SCN5A—which encodes the cardiac sodium channel NaV1.5—to be associated with decreased risk of AF (log(OR) = −0.65, P = 1.3 × 10−12).