This variant is enriched nearly 50-fold in FG (rs143452464:A; Pro41Ser; MAF = 0.023% (UKB) and 1.1% (FG)) and was independently identified in a French family with AF (Supplementary Information), whereas GWAS had linked intergenic variants between PITX2 and FAM241A to AF risk. Here, FAM241A is linked to atrial fibrillation.