For instance, we found the missense variant rs77273740 in DBH (enriched by more than 50-fold in FG)—a gene associated with orthostatic hypotension—to be associated with reduced risk of hypertension (log(OR) = −0.19, P = 1.3 × 10−23), and an in-frame deletion (rs1250342280) in CACNA1D (enriched by 4.3× in UKB)—a gene associated with primary aldosteronism—was associated with increased risk of hypertension (log(OR) = 0.19, P = 2.0 × 10−8) (Table 1). This evidence concerns the gene CACNA1D and hypertensive disorder.