Multiple analyses were performed, grouping cell lines in molecular contexts, including pan-tissue (3 tissues), individual tissues and seven molecular ‘baskets’ representing specific molecular subgroups (TP53, KRAS, PIK3CA, breast PIK3CA, basal-like breast cancers, colon KRAS and colon microsatellite-stable (MSS)) (Fig. 1a). The gene discussed is PIK3CA; the disease is breast carcinoma.