UNC13A CE expression mirrored the known tissue distribution of TDP-43 aggregation and nuclear clearance25: it was specific to ALS-TDP spinal cord and motor cortex, as well as FTLD-TDP frontal and temporal cortices, but was absent from the cerebellum in both disease and control states (Fig. 3b). Here, UNC13A is linked to amyotrophic lateral sclerosis.