The UNC13A CE was detected exclusively in tissues from individuals with FTLD-TDP and ALS-TDP (89% and 38% of individuals, respectively), and not in individuals with non-TDP ALS (caused by SOD1 and FUS mutations), FTLD associated with TAU (FTLD-TAU), FTLD associated with FUS (FTLD-FUS) or controls. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.