As expected, across the NYGC ALS Consortium samples we observed a significant positive correlation between the level of STMN2 CE PSI and UNC13A CE PSI across the NYGC ALS Consortium samples (rho = 0.56, P = 2.9 × 10−7, n = 72 cortical samples) (Extended Data Fig. 7e). This evidence concerns the gene UNC13A and amyotrophic lateral sclerosis.