TNF and neoplasm: We observed a significant decrease in the IL-1β levels in Donepezil (p < 0.001), MN-40(p<0.05) and MN-80 (p < 0.01) treated groups when compared to the tumor + CMF treated group (Fig: 9A). Also a reduction in the levels of IL-6 was observed in Donepezil (p < 0.0001), and both doses of Mulmina, MN-40 (p < 0.05), MN-80 (p < 0.001) (Fig:9C).TNF-α levels were also decreased in the treatment groups, but the differences were not statistically significant compared to the tumor + CMF group (Fig:9B).