But the treatment groups, Donepezil (p < 0.001), MN-40 (p < 0.0001), and MN-80 (p < 0.0001) showed a significant decrease in the BDNF levels when compared to the tumor + CMF group showing the protective effect of the treatments, especially that of MN-40 and MN-80 in reversing the enhanced BDNF levels due to chemotherapy (Fig:9). Here, BDNF is linked to neoplasm.