The chronic inflammatory response-related gene sets such as “IL2 STAT5 signaling”, “interferon-gamma response”, “interferon-alpha response”, “inflammatory response”, “apoptosis”, and “p53 pathway” were found to be significantly associated with poor overall survival across multiple adult cancers including TCGA-LGG, TCGA-UVM, and TCGA-PADD datasets. This evidence concerns the gene TP53 and cancer.