The topmost 46 features were used as input to train and develop the highly discriminating Decision Support System, which is able to distinguish a tumor from a Non-Tumor patient based on the differential expression of three proteins: Topoisomerase 1 (TOP1), Protein Disulfide Isomerase Family A Member 4 (PDIA4) and Osteoglycin (OGN) ,as displayed in Fig. 2. Here, TOP1 is linked to neoplasm.