At the level of RNA export, there are several forms of cancer associated with dysregulation of some nucleoporins (Nup98, Nup214), components of the transcription-export complex TREX (THOC1), and exportines (XPO1, XPO5) that are also included in several nodes of our network and may be worth investigating further for their involvement in HGSOC42–44. The gene discussed is THOC1; the disease is cancer.