Beyond LZTR1, we noted that CRKL (CRK like proto-oncogene, adapter protein), a recurrently amplified gene in multiple carcinomas50–53, including non-small cell lung cancer (3–13% of cases)50–52, was also present in the minimal common region of focal amplification (Fig. 2h). This evidence concerns the gene LZTR1 and non-small cell lung carcinoma.