Kindlin-2 OE resulted in a paler liver (Fig. 3b) and significant increases in the liver weight (Fig. 3c), liver TG content (Fig. 3d) and serum levels of TG (Fig. 3e), TCH (Fig. 3f), NEFA (Fig. 3g), and ALT (Fig. 3h), which all suggest an exacerbation of the NAFLD. The gene discussed is NUCB2; the disease is metabolic dysfunction-associated steatotic liver disease.