Considering that chronic inflammation plays a critical role in NAFLD, we evaluated the influence of Kindlin-2 KD on the inflammatory response and observed that Kindlin-2 KD significantly blocked the PA-induced upregulation of proinflammation factors, such as Tnf-α and Il-6 (Fig. 4d). The gene discussed is IL6; the disease is metabolic dysfunction-associated steatotic liver disease.