Because attenuated weight gain by itself may prevent liver steatosis in the Kindlin-2 Het mice, in the present study, we have additionally used the MCD-induced NAFLD mouse model, which is known to be not associated with weight gain/obesity, to determine whether the protection against NAFLD in Kindlin-2 deficient mice is weight-gain independent. Here, FERMT2 is linked to obesity due to melanocortin 4 receptor deficiency.