Because attenuated weight gain by itself may prevent liver steatosis in the Kindlin-2 Het mice, in the present study, we have additionally used the MCD-induced NAFLD mouse model, which is known to be not associated with weight gain/obesity, to determine whether the protection against NAFLD in Kindlin-2 deficient mice is weight-gain independent. The gene discussed is FERMT2; the disease is metabolic dysfunction-associated steatotic liver disease.