Multiple possible mechanisms may be involved in COVID-19 associated AKI, including SARS-CoV-2-mediated injury, inflammatory response, cytokine storm SARS-CoV-2-induced, activation of the ACE/Ang II pathway, dysregulation of complement, hypercoagulation, and microangiopathy.223 In an autopsy study of 63 COVID-19 patients, the viral RNA presence in the kidneys is correlated with older age and increased comorbidities, as well as reduced survival time. This evidence concerns the gene ACE and COVID-19.