In the context of SARS-CoV-2 infection, cleavage of ACE2 by a disintegrin and metallopeptidase domain 17 (ADAM17) and TMPRSS2 facilitates cell entry.158 This process may lead to ACE2 shedding and loss of protective function of ACE2, subsequently increase Ang II levels and finally induce AT1R stimulation and AT2R inactivation.159 This process triggers the secretion of aldosterone, vasopressin, and adrenocorticotropic hormone (ACTH), hypokalemia, sodium reabsorption, inflammation, cell proliferation, and lung injury. This evidence concerns the gene POMC and Hypokalemia.