IL6 and acute respiratory distress syndrome: Recent studies confirmed the close relationship between alveolar and tubular damage, the lung–kidney cross-talk in ARDS.179 Cytokine such as IL-6 overproduction is involved in lung–kidney bidirectional damage.180 ARDS can induce renal medullary hypoxia, which is an additional insult to tubular cells.180 In addition, lung–heart,181 gut–lung,182 and brain–lung interactions,183 etc., have also been proposed as potential underlying mechanisms of SARS-CoV-2-induced multiorgan dysfunction.