Lymphopenia, particularly in peripheral CD4+ and CD8+ T cells, is frequently found and an early immunologic indicator of impending severe COVID-19.93,94 This lymphocytes depletion could be a manifestation of imbalance in both arms of immune responses, leading to dysregulated IFN production, hyperactivated neutrophils and macrophages, and delayed viral clearance. The gene discussed is CD8A; the disease is lymphopenia.