SAPCD2 and neuroblastoma: Mechanistical studies showed that through direct binding to cytoplasmic E2F7, one of the transcriptional repressors in the E2F family, SAPCD2 altered the subcellular distribution of E2F7 and decreased the level of nuclear E2F7 in NB cells, thus restraining the inhibitory effect of nuclear E2F7 on E2F signaling pathway.