SAPCD2 and neoplasm: To investigate the potential functions of SAPCD2, we then conducted Gene Ontology (GO) enrichment analysis on SAPCD2-correlated genes in 88 specimens (GSE16476), and found that GO terms were significantly enriched in biological processes implicated in chromosome stability, such as chromosome segregation, DNA conformation change and microtubule cytoskeleton organization (Fig. 1H), which play an important role in tumor development and aggressiveness [17].