This leads to ubiquitination and proteasomal degradation of the lymphoid transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), which regulate expression of other genes such as IRF4 and MYC, and are essential for the proliferation and survival of multiple myeloma cells3–7. The gene discussed is IKZF3; the disease is AL amyloidosis.