TGFB1 and neoplasm: In consideration of TGF-β1 is the most prevalent isoform and consistently and significantly correlated with TGF-β signaling activation in many human tumor types (TCGA gene expression data)25, we used TGF-β1(TGF-β agonist) and LY 2157299 (TGF-β inhibitor) to identify the roles of TGF-β signaling in NETs mediated EMT as well as invasion, migration, and proliferation (Fig. 4 and Supplementary Fig. 4).