In the current study, Numb-PRRL promotes TGF-β1- and EGF-induced EMT in PC in vitro and in vivo via regulating TGF-β1-Smad2/3-Snail and EGF-induced EGFR-ERK/MAPK signaling, which has not been reported yet. The gene discussed is TGFB1; the disease is pachyonychia congenita.