CDH1 and cancer: Once an EMT program is activated, cancer cells lose epithelial characteristics (intercellular contacts and polarity) and gain mesenchymal properties (migratory and invasive capacities) following the unbalanced expression of epithelial (E-cad) and mesenchymal biomarkers (Fibronectin, Vimentin, and N-cadherin), which finally contributes to cancer invasion and metastasis [4].