Numerous studies have flagged NF-kB as a focal point for mechanotransductive pathways in various contents (Cowell et al. 2009; Shrum et al. 2009; Tong and Tergaonkar 2014; Ishihara et al. 2019), but gaps in our knowledge remain as to how these pathways may interact and affect breast cancer development. This evidence concerns the gene NFKB1 and breast carcinoma.