GNRH1 and Hyponatremia: On the contrary, Biebermann and colleagues described a new GNAS variant (c.1136 T > G; p.F376V in exon 13) in two unrelated patients presenting a combination of clinical signs similar to those presented by our patient, namely severe asymptomatic hyponatremia in infancy (similar to NSIAD), skeletal and growth plate abnormalities, GnRH-independent precocious puberty and apparent PTH resistance in the proximal but not distal renal tubules.