GZMB and invasive breast carcinoma: We also compared the lymphocyte, immune activation and mutation signature 7 (ultraviolet radiation, UVR) between the low-risk group and the high-risk group in the breast invasive carcinoma (BRCA) and skin cutaneous melanoma (SKCM) cohorts (Additional file 2: Fig. S7D-I); lymphocyte genes (represented by CTLs) were extracted from Jiang et al., including CD8A, CD8B, GZMA, GZMB, and PRF1 [11], and immune activation genes (represented by T and NK cell activity markers) were extracted from Wan et al., including GZMA, GZMB, IFNG, and NKG7 [50].