The general, one-for-all approach was used in the PROSTVAC trial, a viral vector-based immunotherapy consisting of recombinant poxviruses expressing prostate-specific antigen (PSA), together with three immune-enhancing costimulatory molecules, aiming to induce PSA-specific T cell responses, eventually killing PSA-expressing tumour cells [35]. Here, KLK3 is linked to neoplasm.