Prompted by well-documented epidemiological associations between MC1R, pigmentation, and melanoma, and between melanoma and PD as well as possible associations between red hair and PD, and between MC1R variants and PD [19], we previously demonstrated the presence of MC1R in dopaminergic neurons in the mouse substantia nigra (SN) and its influence on dopaminergic neuron survival [20]. This evidence concerns the gene MC1R and melanoma.