These criteria require the presence of at least one clinical event (venous, arterial, or small vessel thrombosis, or pregnancy-related morbidity) and the durable presence over at least 12 weeks of at least one laboratory feature: positive lupus anticoagulant (a functional assay that screens for aPL), anticardiolipin IgG or IgM in medium or high titer (> 40 GPL/MPL or titer > 99th percentile), or anti-beta-2 glycoprotein I (β2GPI) IgG or IgM (titer > 99th percentile) [1]. This evidence concerns the gene CD40LG and systemic lupus erythematosus.